Symbol
Name
ID

Inpp5d
inositol polyphosphate-5-phosphatase D
MGI:107357

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

abnormal granulocyte differentiation

abnormal mononuclear cell differentiation

abnormal monocyte differentiation

abnormal osteoclast differentiation

abnormal macrophage chemotaxis

increased mast cell degranulation

enlarged thymus

small thymus

decreased thymocyte number

enlarged spleen

increased spleen weight

spleen hyperplasia

abnormal definitive hematopoiesis

abnormal erythropoiesis

abnormal lymphopoiesis

abnormal B cell differentiation

decreased pro-B cell number

abnormal T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal myelopoiesis

anemia

decreased bone marrow cell number

increased neutrophil cell number

thrombocytopenia

increased dendritic cell number

abnormal lymphocyte cell number

absent marginal zone B cells

increased B-1 B cell number

decreased B cell number

decreased pre-B cell number

decreased NK cell number

increased NK cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased alpha-beta T cell number

decreased lymphocyte cell number

increased macrophage cell number

increased osteoclast cell number

increased monocyte cell number

increased leukocyte cell number

abnormal lymphocyte morphology

abnormal NK cell morphology

abnormal osteoclast morphology

abnormal spleen marginal zone macrophage morphology

abnormal myeloid leukocyte morphology

abnormal leukocyte physiology

abnormal eosinophil physiology

abnormal neutrophil physiology

abnormal B cell physiology

increased IgG2a level

increased IgG level

increased IgM level

increased immunoglobulin level

impaired natural killer cell mediated cytotoxicity

abnormal T cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

abnormal cytotoxic T cell physiology

decreased cytotoxic T cell cytolysis

abnormal osteoclast physiology

abnormal platelet activation

decreased platelet aggregation

abnormal bone marrow cell physiology

Availability

Mouse Genotype

Inpp5d^el20/Inpp5d^el20

Inpp5d^m1Btlr/Inpp5d^m1Btlr

Inpp5d^m2Btlr/Inpp5d^m2Btlr

Inpp5d^m5Btlr/Inpp5d^m5Btlr

Inpp5d^tm1.1Wgk/Inpp5d^tm1.1Wgk

Inpp5d^tm1Dmt/Inpp5d^tm1Dmt

Inpp5d^tm1Rkh/Inpp5d^tm1Rkh

Inpp5d^M3Btlr/Inpp5d⁺

Inpp5d^tm1Rav/Inpp5d^tm1Rav
Tg(Cd4-cre)1Cwi/? (conditional)

Cd79a^tm1(cre)Reth/Cd79a⁺
Inpp5d^tm1Rav/Inpp5d^tm1Rav (conditional)

Inpp5d^tm1Rav/Inpp5d^tm1.1Rav
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Inpp5d^tm1Wgk/Inpp5d^tm1.1Wgk
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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